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Urokinase plasminogen activator receptor (CD87): something old, something new
1Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0743, USA.
Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
|June 28, 2003
Summary
CD87, a receptor for urokinase plasminogen activator (uPA), regulates cell functions and is implicated in tumor invasion and metastasis. Targeting CD87 offers promising therapeutic strategies for malignant tumors.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- CD87 is a receptor for urokinase plasminogen activator (uPA).
- It plays a key role in regulating cell-surface plasminogen activation.
- CD87 is involved in various physiological and pathological processes, including cell adhesion, motility, angiogenesis, tumor invasion, and metastasis.
Purpose of the Study:
- To explore the therapeutic potential of CD87.
- To investigate targeting strategies for CD87 in cancer therapy.
Main Methods:
- Review of existing evidence on CD87 function and interactions.
- Analysis of CD87's role in tumor invasion and metastasis.
- Exploration of therapeutic strategies targeting CD87 interactions and expression.
Main Results:
- CD87 is a pleiotropic molecule mediating diverse cellular events beyond plasminogen activation.
- CD87 interacts with molecules like integrins and L-selectin.
- CD87 overexpression correlates with tumor invasion.
Conclusions:
- Targeting CD87 interactions with uPA, other molecules, or its gene expression presents a promising therapeutic avenue.
- Therapeutic strategies targeting CD87 hold potential for treating malignant tumors.
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