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Updated: Jul 24, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
A man with palpable purpuric hand lesions.
G Matfin1, J S Vasta, A D'Agostino
1Department of Medicine, University of South Florida College of Medicine, James A. Haley Veterans Affairs Medical Center, Tampa, USA.
A 75-year-old man with seronegative rheumatoid arthritis developed fever, joint pain, and skin lesions. This case highlights potential cutaneous manifestations in rheumatoid arthritis patients.
Area of Science:
- Rheumatology
- Dermatology
Background:
- Seronegative rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
- Patients with RA can experience extra-articular manifestations.
Observation:
- A 75-year-old male patient with pre-existing seronegative RA presented with acute symptoms.
- Symptoms included low-grade fever, new-onset arthralgias, oral ulcerations, and bilateral hand cutaneous lesions.
Findings:
- The patient's presentation suggests a potential flare or complication of seronegative RA.
- Cutaneous hand lesions and oral sores are notable extra-articular findings.
Implications:
- This case underscores the importance of considering dermatological and systemic symptoms in RA management.
- Early recognition of these manifestations may guide treatment adjustments and improve patient outcomes.
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