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Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark
Emmanuel Talla1, Dieudonné Njamen, Joseph Tanyi Mbafor
1Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.
Journal of Natural Products
|June 28, 2003
Abstract:
The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.