Related Experiment Video
Updated: Aug 9, 2026
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Clinical evaluation of a new measles-mumps-rubella trivalent vaccine
Insights
This study found that the combined measles, mumps, and rubella vaccine is safe and effective. It demonstrated high seroconversion rates and comparable safety profiles to single-strain vaccines in children.
Area of Science:
- Immunology
- Vaccinology
- Pediatrics
Background:
- Measles, mumps, and rubella are significant infectious diseases in children.
- Combined vaccines offer a convenient method for immunization.
- Evaluating the safety and efficacy of novel vaccine combinations is crucial.
Purpose of the Study:
- To assess the safety and immunogenicity of a combined measles, mumps, and rubella (MMR) vaccine.
- To compare the reaction profile of the combined MMR vaccine to monovalent measles vaccine.
- To determine seroconversion rates and antibody titers following administration of the combined MMR vaccine.
Main Methods:
- Clinical studies involving 1,481 children who received either the combined MMR vaccine or a placebo.
- Monitoring for adverse reactions and recording their frequency and severity.
- Assessing seroconversion rates and geometric mean antibody titers in vaccine recipients.
Main Results:
- The combined MMR vaccine showed no significant adverse reactions.
- Mild, transient fever or rash occurred with similar frequency as with the monovalent measles vaccine.
- Seroconversion rates for measles, mumps, and rubella ranged from 95% to 100%.
- Geometric mean antibody titers were comparable to those achieved with monovalent vaccines.
Conclusions:
- The combined measles, mumps, and rubella vaccine is safe and well-tolerated in children.
- The vaccine elicits robust immune responses, achieving high seroconversion rates.
- This combination vaccine provides an effective immunization strategy against these three viral diseases.
Abstract:
In a series of clinical studies of a combined measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) vaccine, 1,481 children received the vaccine or a placebo. The vaccine did not cause any significant reactions. The frequencies of mild, transient fever or rash or both in triple-susceptible vaccinees were similar to those that follow use of Schwarz strain measles vaccine alone. Measles, mumps, and rubella seroconversion rates in triple-susceptible vaccinees ranged from 95% to 100%. Geometric mean antibody titers were as high as those that usually result from use of these same virus strains as monovalent vaccines.
