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The hypothalamic-pituitary-adrenal axis and viral infection
Michael Bailey1, Harald Engler, John Hunzeker
1Section of Oral Biology, Colleges of Dentistry, Medicine and Public Health, The Ohio University Health Sciences Center, Columbus, Ohio 43218-2357, USA.
Viral Immunology
|June 28, 2003
Abstract:
The hypothalamic-pituitary-adrenal (HPA) axis plays an important immunomodulatory role during viral infection. Activation of the HPA axis ultimately leads to elevated plasma levels of glucocorticoid (GC) hormones with the ability to mediate adaptive behavioral, metabolic, cardiovascular and immune system effects. In this review, we focus on the modulation of anti-viral immunity and viral pathogenesis by the HPA axis.