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Updated: Sep 23, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling
Anne M Johnston1, Luciano Pirola, Emmanuel Van Obberghen
1INSERM Unit 145, IFR 50, Faculty of Medicine, Nice, France.
Abstract:
The insulin receptor substrate (IRS) proteins act as important mediators of insulin action. Their regulation serves to augment the specificity of the insulin signalling cascade. They can be regulated--both positively and negatively--at the level of phosphorylation, and signalling through these proteins can be further modulated through the actions of SOCS (suppressor of cytokine signalling) proteins. Understanding the mechanisms of IRS regulation will provide further insight into the pathophysiology of insulin resistance and type 2 diabetes.
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