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Related Experiment Videos

Nickel uptake and utilization by microorganisms.

Scott B Mulrooney1, Robert P Hausinger

  • 1Department of Microbiology and Molecular Genetics, 6193 Biomedical Physical Sciences, Michigan State University, East Lansing, MI 48824, USA.

FEMS Microbiology Reviews
|June 28, 2003
PubMed
Summary
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Nickel is an essential nutrient for microbes, vital for cellular processes and incorporated into nine known nickel-dependent enzymes. Seven of these enzymes have been structurally characterized, showing unique metallocenter environments.

Area of Science:

  • Microbiology
  • Biochemistry
  • Structural Biology

Background:

  • Nickel is an essential micronutrient for many microorganisms.
  • Microbes regulate nickel ion concentration through specific transport systems.
  • Nickel is a crucial component of various essential enzymes.

Purpose of the Study:

  • To review the known nickel-dependent enzymes in microorganisms.
  • To highlight the structural characterization of these nickel-containing enzymes.
  • To discuss the assembly and function of nickel ions in microbial cellular processes.

Main Methods:

  • Literature review of nickel-dependent enzymes.
  • Analysis of structural data for characterized nickel-containing enzymes.
  • Summary of nickel uptake and incorporation mechanisms.

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Main Results:

  • Nine nickel-dependent enzymes have been identified in microorganisms.
  • Seven of these enzymes have been structurally characterized.
  • Distinct metallocenter environments exist within these nickel-dependent enzymes.

Conclusions:

  • Nickel plays a critical role in microbial physiology through its incorporation into essential enzymes.
  • Structural studies reveal diverse active site architectures for nickel-dependent enzymes.
  • Understanding nickel metabolism and enzyme function is crucial for microbial biotechnology and medicine.