Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin dynamics and locus accessibility in the immune system.

Raul Mostoslavsky1, Frederick W Alt, Craig H Bassing

  • 1Howard Hughes Medical Institute, Children's Hospital, Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature Immunology
|June 28, 2003
PubMed
Summary

Cellular differentiation in vertebrates involves precisely controlled gene expression. This ensures cells maintain their unique identities and pass on genetic information to daughter cells during development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.

PLoS pathogens·2026
Same author

Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.

Nature communications·2026
Same author

Author Correction: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Nature communications·2026
Same author

Linear RAG scanning mediates editing of Igκ variable region repertoires.

Nature·2026
Same author

Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human V<sub>H</sub>1-2-rearranging mouse models.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells.

Nature communications·2026

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Vertebrate development involves progressive cellular differentiation from a single zygote.
  • Despite differentiation, most cells retain identical genetic material.
  • Acquiring and maintaining distinct cell identities requires regulated gene expression.

Purpose of the Study:

  • To explain the mechanisms of cellular differentiation in vertebrates.
  • To highlight the importance of regulated gene expression in cell identity.
  • To describe the heritable nature of gene expression in differentiated cells.

Main Methods:

  • This study is a review of existing literature on cellular differentiation.
  • Analysis of gene expression patterns during vertebrate development.

Related Experiment Videos

  • Examination of epigenetic mechanisms maintaining cell identity.

    • Main Results:

    • Cellular differentiation pathways are distinct in vertebrates.
    • Regulated gene activation and silencing are crucial for cell identity.
    • Terminally differentiated cells maintain 'heritable' gene expression patterns.

    Conclusions:

    • Cellular differentiation is a fundamental process in vertebrate development.
    • Precise control of gene expression ensures cell-specific functions.
    • Heritable gene expression is essential for maintaining cell identity across cell divisions.