Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Warfarin treatment and bleeding].

Anne Berg Breen1, Trine Elise Vaskinn, Asmund Reikvam

  • 1Institutt for farmakoterapi, Det medisinske fakultet, Universitetet i Oslo, Postboks 1065 Blindern, 0316 Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 28, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Community health worker-facilitated home visits for hypertension management in urban Nepal: a mixed-methods process evaluation.

BMJ open·2026
Same author

Association Between Anticholinergic Burden and Dry Mouth Severity in Acutely Ill Older Adults.

Drugs & aging·2026
Same author

[Which variables should be included in a regression model?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2026
Same author

Collaborative medication reviews during acute primary care admissions for older adults with polypharmacy: a randomised controlled trial.

Age and ageing·2026
Same author

Correction: Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus.

Frontiers in neurology·2025
Same author

Cognitive profile and frailty in patients with idiopathic normal pressure.

Frontiers in neurology·2025

Warfarin-related bleeding complications are common in elderly patients, particularly during initial treatment. High International Normalized Ratio (INR) values significantly increase bleeding risk, necessitating careful monitoring and dose adjustment.

Area of Science:

  • Pharmacovigilance
  • Clinical Pharmacology
  • Internal Medicine

Context:

  • Warfarin is a widely prescribed anticoagulant associated with a high incidence of fatal adverse drug events.
  • Hemorrhagic complications represent a significant safety concern in warfarin therapy.
  • Identifying risk factors for bleeding is crucial for improving patient safety.

Purpose:

  • To identify risk factors associated with hemorrhagic complications in patients treated with warfarin.
  • To analyze adverse event reports of warfarin-induced bleeding.

Summary:

  • A review of 713 adverse event reports (1990-2000) involving warfarin-related bleeding revealed that 71% of affected patients were over 70 years old.
  • High International Normalized Ratio (INR) values (mean 4.4, with 74% above recommended limits) and early treatment initiation (63% within the first month, 30% within five days) were strongly associated with bleeding events.

Related Experiment Videos

  • Cerebral and gastrointestinal bleedings were frequent and often fatal, with shorter treatment durations observed in fatal cases.

    • Impact:

    • Findings highlight the critical need for enhanced patient monitoring and meticulous dose adjustments during warfarin therapy.
    • Emphasizes maintaining INR values within the lower end of recommended ranges to mitigate bleeding risks.
    • Suggests that simple strategies focusing on monitoring and dose titration can significantly reduce warfarin-associated hemorrhages.