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[Association between Bam HI RFLP p53 gene polymorphism and brain infarction volume in patients with atherothrombotic
Abstract:
A significant association between Bam HI RFLP p53 gene polymorphism and brain infarction volume in patients with atherothrombotic ischemic stroke (AIS) from Moscow population was found. Biallelic Bam HI polymorphism in exon 5 of p53 gene was studied in 96 AIS patients, 100 their healthy siblings, 41 patients with chronic ischemic disease and 42 their healthy siblings. Magnetic resonance tomography with morphometric program "Osiris" (the Hospital of the University, Geneva) for infarction volume measuring was used on day 1 and 7 after stroke onset. The patients with (-/-) p53 Bam HI genotype had the smaller brain infarction sizes (< 40 cm3), comparing to those with (-/+) (chi 2 = 19.7; p < 0.001) and (+/+) (chi 2 = 12.3; p < 0.001) genotypes. According to Bayes statistics, development of smaller infarction size in AIS may be predicted with over than 65% probability in the patients with (-/-) p53 Bam HI genotype. A significant association between p53 Bam HI polymorphism and infarction volume in patients with carotid atherothrombotic stroke confirms an important role of apoptosis in ischemic brain lesions formation that demands temporary antiapoptotic influence on patients with stroke.
Insights
The p53 Bam HI gene polymorphism is linked to brain infarction volume in Moscow's atherothrombotic ischemic stroke (AIS) patients. Individuals with the (-/-) genotype showed smaller infarcts, suggesting a role for apoptosis in stroke outcomes.
Area of Science:
- Genetics
- Neurology
- Molecular Biology
Background:
- Ischemic stroke (AIS) involves complex genetic and molecular factors.
- The p53 gene plays a role in apoptosis, a key process in cellular damage.
- Understanding genetic predispositions can aid in predicting stroke severity.
Purpose of the Study:
- To investigate the association between p53 gene polymorphism (Bam HI RFLP) and brain infarction volume in AIS patients.
- To explore the role of apoptosis in the pathogenesis of ischemic brain lesions.
Main Methods:
- Study included 96 AIS patients, 100 healthy siblings, 41 chronic ischemic disease patients, and 42 healthy siblings from Moscow.
- Genotyping focused on the biallelic Bam HI polymorphism in exon 5 of the p53 gene.
- Brain infarction volume was measured using Magnetic Resonance Tomography (MRT) with the "Osiris" morphometric program on days 1 and 7 post-stroke.
Main Results:
- A significant association was found between p53 Bam HI polymorphism and brain infarction volume in AIS patients.
- Patients with the (-/-) p53 Bam HI genotype exhibited smaller infarct volumes (< 40 cm3) compared to (-/+) and (+/+) genotypes (p < 0.001).
- Bayes statistics indicated a >65% probability of smaller infarct size in AIS patients with the (-/-) p53 Bam HI genotype.
Conclusions:
- The p53 Bam HI polymorphism is significantly associated with infarction volume in carotid atherothrombotic stroke.
- This finding highlights the critical role of apoptosis in the formation of ischemic brain lesions.
- Targeted anti-apoptotic therapies may be beneficial for stroke patients with specific p53 genotypes.