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Related Experiment Videos

Sch 1000: a new anticholinergic bronchodilator.

M J Gross

    The American Review of Respiratory Disease
    |December 1, 1975
    PubMed
    Summary

    Sch 1000, an atropine derivative, offers bronchodilator effects for asthma treatment. While slower to act than isoproterenol, it provides longer-lasting relief with fewer side effects.

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    Area of Science:

    • Pharmacology
    • Pulmonary Medicine

    Background:

    • Asthma management often involves bronchodilators.
    • Atropine derivatives are explored for their potential therapeutic benefits.

    Purpose of the Study:

    • To evaluate the bronchodilator efficacy and safety of Sch 1000 in asthmatic subjects.
    • To compare the onset, duration, and maximal effect of Sch 1000 with isoproterenol.

    Main Methods:

    • A double-blind, controlled study involving inhaled administration of Sch 1000 at varying doses (10-80 mug) to asthmatic patients.
    • Measurement of bronchodilator response using forced expiratory volume in 1 second (FEV1) and maximal mid-expiratory flow (MMEF).

    Main Results:

    • Sch 1000 demonstrated bronchodilator activity with an onset of 15-30 minutes and a duration of 4 hours, compared to isoproterenol's 5-minute onset and 1-hour duration.
    • Maximal bronchodilatation with Sch 1000 was comparable to, but not greater than, isoproterenol.
    • Dose-response analysis indicated maximal effect at 10-20 mug of Sch 1000.
    • Sch 1000 showed a significantly greater increase in MMEF than FEV1.
    • Fewer side effects were observed with Sch 1000 compared to isoproterenol, with no apparent atropine-like effects.

    Conclusions:

    • Sch 1000 is an effective bronchodilator for asthma with a favorable duration of action and safety profile.
    • The optimal therapeutic dose for Sch 1000 appears to be between 10 and 20 mug.
    • Sch 1000 presents a viable alternative to isoproterenol, particularly for patients sensitive to side effects.

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