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Updated: Aug 28, 2026

Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates
Published on: October 18, 2018
[Integer multiple rhythm in the spontaneous beating rhythm of cardiac myocytes and its possible mechanism]
Zhi-qiang Liu1, Hua-guang Gu, Ming-hao Yang
1Institute of Space Medico-Engineering, Beijing, China.
Objective:
To introduce the characteristics of the integer multiple rhythm of cultured cardiac myocytes and to explore the cause of its generation.
Method:
Spontaneous beating rhythms of cultured cardiac myocytes were observed with photometry system and stochastic Chay model was used to simulate the experimental results.
Result:
Integer multiple rhythm was observed in the experiment. This kind of rhythm is similar to phenomena of sinus arrest. The integer multiple rhythm similar to that of the experiments was simulated in stochastic Chay model, and was demonstrated to be induced by the mechanism of autonomous stochastic resonance.
Conclusion:
The integer multiple rhythm observed in the experiment might be generated via the effect of autonomous stochastic resonance.
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