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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Weightlessness01:01

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When an object is dropped, it accelerates toward the center of the Earth. If the net external force on the object is its weight, it is said to be in free fall; that is, the only force acting on the object is gravity. Galileo was instrumental in showing that, in the absence of air resistance, all objects fall with the same acceleration g. However, when objects on the Earth fall downward, they are never truly in free fall, because there is always some upward resistance force from the air acting...
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Nucleosome Remodeling02:54

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
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Seedless Vascular Plants Were the First Tall Plants on Earth
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Vascular Spasm01:16

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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Related Experiment Video

Updated: Feb 10, 2026

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
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[Weightlessness or weightlessness simulation and vascular remodeling].

Yong Yue, Yong-jie Yao, Xi-qing Sun

    Hang Tian Yi Xue Yu Yi Xue Gong Cheng = Space Medicine & Medical Engineering
    |July 2, 2003
    PubMed
    Summary
    This summary is machine-generated.

    Weightlessness causes significant physiological changes, particularly vascular remodeling in the cardiovascular system. Understanding this remodeling is crucial for addressing orthostatic intolerance after spaceflight.

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    Area of Science:

    • Cardiovascular Physiology
    • Space Medicine
    • Vascular Biology

    Context:

    • Spaceflight exposes astronauts to weightlessness, inducing physiological adaptations.
    • Cardiovascular system alterations, including vascular remodeling, are key concerns.
    • Orthostatic intolerance is a common post-flight issue linked to cardiovascular changes.

    Purpose:

    • To review recent studies on weightlessness-induced vascular remodeling.
    • To discuss the mechanisms underlying cardiovascular changes during spaceflight.
    • To explore the link between vascular remodeling and post-flight orthostatic intolerance.

    Summary:

    • Weightlessness significantly impacts vascular remodeling within the cardiovascular system.
    • Studies show weightlessness or simulated weightlessness alters blood vessel structure and function.
    • Mechanisms of weightlessness-related cardiovascular remodeling are explored.

    Impact:

    • Findings may elucidate the causes of orthostatic intolerance after space missions.
    • Provides a foundation for developing countermeasures against spaceflight-induced cardiovascular deconditioning.
    • Highlights the importance of studying vascular remodeling for astronaut health and long-duration space exploration.