Related Experiment Video
Updated: Aug 17, 2026

Isolation and Expansion of Adult Canine Hippocampal Neural Precursors
Published on: November 29, 2016
Cryptococcosis of the central nervous system in a dog
Therese E O'Toole1, Amy F Sato, Elizabeth A Rozanski
1Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Abstract:
A 3-year-old female German Shepherd Dog was evaluated for progressive mental obtundation and vestibular signs. Central nervous system cryptococcosis was diagnosed on the basis of growth of Cryptococcus neoformans in fungal culture of CSF, as well as detection of the organism in CSF via microscopy. Cryptococcal capsular latex antigen agglutination titer was 1:262,144 in CSF and 1:1,048,576 in serum samples. Imaging with magnetic resonance augmented diagnosis. The dog improved after long-term treatment with fluconazole. Fluconazole is useful in the treatment of CNS cryptococcosis, because it attains high concentration in the CNS. Long-term therapy is often required for resolution of clinical signs, and affected animals may require long-term follow-up with periodic evaluation of CSF via fungal culture and latex agglutination tests. Monitoring serum latex agglutination test results may provide a safe, less invasive means of monitoring response to treatment.
Related Concept Videos
Rabies
Cryptococcal Meningitis
Toxoplasmosis
Encephalitis ll: Pathophysiology
Brain Abscess l: Introduction
Hepatic Encephalopathy

