Origins and manifestations of oocyte maturation competencies

Mammalian oocytes acquire a series of competencies during follicular development that play critical roles at fertilization and subsequent stages of preimplantation embryonic development. These competencies involve remodelling of chromatin and the cytoskeleton in the oocyte at critical stages of folliculogenesis when gametes and somatic cells communicate by paracrine and junctional mechanisms. While the detailed steps involved in bi-directional signalling between oocytes and granulosa cells remain unknown, studies from mice bearing targeted deletions in essential 'communication' genes reveal selective disturbances in oocyte maturation competencies that compromise the oocyte's developmental potential. Recent data are reviewed that illustrate the general principle that competencies acquired at sequential stages of oogenesis are manifest during oocyte growth, maturation, or following fertilization. The recognition that oocyte-specific genes are called into play at key developmental transitions in mammalian embryogenesis emphasizes the importance of monitoring genetic and epigenetic determinants when using current assisted reproductive technologies manipulations.