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Updated: Sep 23, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
From subgenome analysis to protein structure
Orna Man1, Tal Atarot, Avital Sadot
1The Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel.
Abstract:
Groups of related genes abound in large eukaryotic genomes. In such 'subgenomes', homology modeling carried out for a few genes will probably have relevance to the entire group. Subgenomes also afford unique ways of determining protein structural information. In addition to analyses based on the quantification of residue variability in paralogs, two-way comparisons, both within and among species, help to disclose functional amino acids. Comparative studies of gene families throughout the mammalian genome will also help elucidate the functional significance of single nucleotide polymorphisms in coding regions.
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