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A structural perspective on genome evolution.

David Lee¹, Alastair Grant, Daniel Buchan

¹Department of Biochemistry and Molecular Biology, University College, Gower Street, WC1E 6BT, London, UK. dlee@biochem.ucl.ac.uk

Current Opinion in Structural Biology

|July 2, 2003

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Protein structural annotations from over 100 genomes reveal conserved and unique domain architectures across life. This diversity in protein structures explains varied phenotypes and suggests new targets for structural genomics.

Area of Science:

Genomics
Structural Biology
Evolutionary Biology

Background:

Over 100 complete genome translations are available.
Structural annotation is available for approximately half of these genomes.
Understanding protein and pathway evolution is crucial.

Purpose of the Study:

To investigate the insights gained from structural annotation of complete genomes.
To explore the combination of domain structures in multidomain proteins.
To understand the contribution of domain architectures to diverse phenotypes.

Main Methods:

Analysis of protein translations from over 100 complete genomes.
Application of structural annotation to protein sequences.
Comparison of domain architectures across different kingdoms of life and individual genomes.

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Main Results:

Major domain structure families are conserved across all kingdoms of life.
Multidomain proteins exhibit diverse domain architectures specific to kingdoms or genomes.
These domain architectures contribute significantly to observed phenotypic diversity.

Conclusions:

Structural annotation of genomes provides profound insights into protein and pathway evolution.
Domain architecture diversity is a key factor in biological diversity.
Structural genomics initiatives should target diverse domain architectures to enhance understanding of protein function.