A structural perspective on genome evolution
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Updated: Aug 12, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells
Published on: January 25, 2020
David Lee1, Alastair Grant, Daniel Buchan
1Department of Biochemistry and Molecular Biology, University College, Gower Street, WC1E 6BT, London, UK. dlee@biochem.ucl.ac.uk
Abstract:
Protein translations of over 100 complete genomes are now available. About half of these sequences can be provided with structural annotation, thereby enabling some profound insights into protein and pathway evolution. Whereas the major domain structure families are common to all kingdoms of life, these are combined in different ways in multidomain proteins to give various domain architectures that are specific to kingdoms or individual genomes, and contribute to the diverse phenotypes observed. These data argue for more targets in structural genomics initiatives and particularly for the selection of different domain architectures to gain better insights into protein functions.
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