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Neuromorphological background of cannabis addiction
Tibor Wenger1, Gabriella Moldrich, Susanna Furst
1Department of Human Morphology and Developmental Biology, Semmelweis University, Tuzolto u. 58, PO Box 95, Budapest, Hungary. wenger@ana2.sote.hu
Abstract:
The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures.