Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurodevelopmental liabilities in epilepsy.

Antonio Gil-Nagel1

  • 1Programa de Epilepsia, Servicio de Neurología, Hospital Ruber Internacional, La Masó 38, Mirasierra, 28034 Madrid, Spain.

Neurotoxicity Research
|July 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prolonged fenfluramine use in open-label studies of Dravet or Lennox-Gastaut syndromes: Long-term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness.

Epilepsia·2026
Same author

Human hippocampal ripples tune cortical responses based on predicted uncertainty.

Nature neuroscience·2026
Same author

Practical Recommendations for Cardiology Follow-Up in Patients Treated with Fenfluramine Based on Expert Opinion and Clinical Experience.

Neurology and therapy·2026
Same author

Seizure-free days as a clinical outcome measure of reduced epilepsy burden: 5-year outcomes with cenobamate treatment.

Epilepsy & behavior : E&B·2026
Same author

Teaching Video NeuroImage: Tapping-Triggered Seizure Secondary to Focal Cortical Dysplasia in the Primary Somatosensory Cortex.

Neurology·2025
Same author

Fenfluramine for developmental and epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS): An exploratory study.

Epilepsy research·2025

Epilepsies are cortical disorders involving excessive neuronal activity. Their mechanisms include channelopathies, excitotoxicity, and neuronal organization issues, illustrated by specific epilepsy types.

Area of Science:

  • Neuroscience
  • Neurology
  • Epileptology

Background:

  • Epilepsies are a diverse group of cortical disorders defined by recurrent excessive neuronal activity.
  • Understanding the underlying pathophysiology is crucial for developing effective treatments.

Purpose of the Study:

  • To review the complex mechanisms contributing to the pathophysiology of epilepsies.
  • To illustrate these mechanisms using three distinct epilepsy examples.

Main Methods:

  • Review of existing literature on epilepsy mechanisms.
  • Case-based analysis of autosomal dominant nocturnal frontal lobe epilepsy, mesial temporal sclerosis, and cortical malformations.

Main Results:

  • Identified key pathophysiological mechanisms including channelopathies, excitotoxic processes, and neuronal disorganization.

Related Experiment Videos

  • Demonstrated how these mechanisms manifest in specific epilepsy syndromes.

    • Conclusions:

    • The pathophysiology of epilepsies is multifactorial, involving genetic, cellular, and organizational disruptions.
    • Studying specific epilepsy types provides valuable insights into broader epileptogenic processes.