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[EBV in malignant lymphomas]
S Handt1, K Hoffmeister, K Wilgenbus
1Institut für Pathologie, Rheinisch-Westfälischen Technischen Hochschule, Aachen.
Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1992
Abstract:
PCR and in-situ-Hybridization were used to detect EBV-DNA within Hodgkin- and Non-Hodgkin-Lymphomas. By the use of primers for the Bam H1 W fragment we could show EBV-DNA to be associated with 45% Hodgkin- and 25% T-Lymphomas, whereas we could not find EBV-DNA within B-Lymphomas. In about one third of the PCR-positive cases we could localize EBV-DNA mostly in the tumor cell nuclei by in-situ-hybridization.