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Related Experiment Videos

Nifedipine inhibits the hypoxia-induced decrease in plasma renin activity in conscious dogs.

C Höhne1, E Arntz, M O Krebs

  • 1Experimental Anesthesia, Clinic of Anesthesiology and Surgical Intensive Care Medicine, Campus Virchow-Klinikum, Charité, Berlin, Germany. claudia.hoehne@charite.de

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|July 2, 2003
PubMed
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Acute hypoxia lowers plasma renin activity (PRA), angiotensin II (AngII), and aldosterone (PAC). Nifedipine, a calcium channel blocker, prevented these decreases, suggesting L-type calcium channels mediate hypoxia's effects on PRA.

Area of Science:

  • Physiology
  • Cardiovascular Research
  • Renal Physiology

Background:

  • Acute hypoxia typically reduces plasma renin activity (PRA), leading to lower angiotensin II (AngII) and plasma aldosterone concentration (PAC).
  • This reduction is thought to involve mechanisms like increased adenosine, calcium channel activity, or inhibited ATP-sensitive potassium channels.

Purpose of the Study:

  • To investigate if the L-type voltage-dependent calcium channel antagonist nifedipine can inhibit hypoxia-induced decreases in PRA, AngII, and PAC.
  • To explore the role of L-type calcium channels in the renin-angiotensin-aldosterone system response to hypoxia.

Main Methods:

  • Eight conscious dogs with chronic tracheotomies were studied under a low sodium diet.
  • Dogs received either nifedipine infusion or a control treatment in a randomized crossover design.

Related Experiment Videos

  • Measurements of PRA, AngII, and PAC were taken during normoxia and subsequent hypoxia (inspiratory oxygen fraction of 0.1).

    • Main Results:

    • In control conditions, hypoxia significantly decreased PRA, AngII, and PAC.
    • Nifedipine administration during hypoxia resulted in increased PRA and AngII levels.
    • The hypoxia-induced decrease in PAC was significantly blunted in the nifedipine group compared to controls.

    Conclusions:

    • Hypoxia-induced reduction in PRA appears to involve L-type calcium channel activity.
    • Nifedipine can counteract the suppressive effects of hypoxia on the renin-angiotensin-aldosterone system.
    • L-type calcium channels are a key component in mediating the hormonal response to acute hypoxia.