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[Malignant lymphomas in spleen--morphology and microenvironment].

S Falk1

  • 1Senckenbergisches Zentrum der Pathologie, J. W. Goethe Universität Frankfurt/Main.

Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1992
PubMed
Summary

Malignant lymphomas in the spleen show specific infiltration patterns that aid diagnosis. These patterns arise from complex, not fully understood, interactions between cancer cells and normal spleen cells.

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The CONVERT Trial: Interpretation, Journey and Lessons Learnt.

Clinical oncology (Royal College of Radiologists (Great Britain))·2017

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Malignant lymphomas in the spleen present unique infiltration patterns.
  • Understanding these patterns is crucial for accurate diagnosis and staging.
  • The interplay between neoplastic and non-neoplastic splenic cells is complex and incompletely understood.

Purpose:

  • To elucidate the characteristic stage-dependent infiltration patterns of splenic malignant lymphomas.
  • To explore the interactions between neoplastic and non-neoplastic splenic cell populations.
  • To investigate the factors governing these cellular interactions for diagnostic insights.

Summary:

  • Splenic malignant lymphomas exhibit distinct infiltration patterns correlating with disease stage.
  • These patterns are driven by intricate interactions between cancerous and normal splenic cells.
  • Factors include intrinsic cell properties (receptors, cytokines) and extrinsic splenic microenvironment characteristics.

Impact:

  • Provides a basis for improved diagnostic strategies for splenic lymphomas.
  • Enhances understanding of lymphoma behavior within the splenic microenvironment.
  • May inform future therapeutic approaches targeting splenic lymphoma interactions.

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