Related Experiment Video
Updated: Aug 15, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Abdominal aortic aneurysms and concomitant coronary artery disease. Is routine dipyridamole thallium scintigraphy
1Department of Surgery, Royal Berkshire Hospital, Reading, UK. Robert.Galland@rbbh-tr.nhs.uk
Insights
Identifying coronary artery disease in peripheral vascular disease patients undergoing abdominal aortic aneurysm repair is crucial. Routine cardiac investigations like dipyridamole thallium scanning are not justified due to lack of proven benefit.
Area of Science:
- Cardiology
- Vascular Surgery
- Diagnostic Imaging
Background:
- High prevalence of coronary artery disease (CAD) in peripheral vascular disease (PVD) patients.
- Cardiac complications are the leading cause of perioperative death after abdominal aortic aneurysm (AAA) repair.
- Risk stratification for perioperative cardiac events is possible through clinical assessment and investigations.
Purpose of the Study:
- To evaluate the utility of dipyridamole thallium scanning (DTS) in identifying myocardial ischemia in PVD patients undergoing AAA repair.
- To determine if identifying and correcting CAD improves perioperative mortality or long-term survival in these patients.
Main Methods:
- Review of dipyridamole thallium scanning (DTS) findings in patients with PVD.
- Analysis of evidence regarding the impact of CAD identification and correction on perioperative outcomes.
- Consideration of risk stratification methods including clinical evaluation, stress testing, and ejection fraction measurement.
Main Results:
- DTS reveals normal scans, reversible defects, or fixed defects in approximately one-third of PVD patients.
- Delayed scans indicate some "fixed" defects are reversible, suggesting myocardial ischemia.
- No evidence supports improved operative mortality or long-term survival from identifying and treating CAD in asymptomatic patients.
Conclusions:
- Routine use of DTS or other cardiac investigations for all PVD patients undergoing AAA repair is not justified.
- While high-risk patients may warrant investigation, optimizing medical treatment may be preferable to revascularization or delaying aneurysm repair.
- The benefit of identifying and correcting CAD in asymptomatic patients undergoing AAA repair remains unproven.
Abstract:
There is a high prevalence of coronary artery disease in patients with peripheral vascular disease (PVD). Following elective abdominal aortic aneurysm (AAA) repair the commonest cause for perioperative death is cardiac-related. Patients at high risk of developing perioperative adverse cardiac events can be identified. Means of identification include clinical history and examination with or without the calculation of a scoring index, stress testing and measurement of ejection fractions. The use of dipyridamole thallium scanning (DTS) in patients with PVD results in about 1/3 of patients having normal scans, 1/3 showing reversible and 1/3 fixed defects. It has been generally accepted that fixed defects represent a completed myocardial infarction and patients are at no greater risk of developing perioperative cardiac complications than those patients with normal scans. However, delayed scans show that some of these "fixed" defects are in fact reversible. Evidence of a redistribution defect implies myocardial ischaemia. The debate centres on whether identification of such defects and their correction will improve perioperative mortality following AAA repair. There is no evidence that identification and correcting coronary artery disease in asymptomatic patients results either in improved operative mortality or long-term survival. "Routine" use of DTS or any other means of cardiac investigation cannot be justified. Patients who clinically fall into a "high risk" category perhaps should be investigated but a case could be made for simply optimising their medical treatment and not carrying out either coronary revascularisation or aneurysm repair.
More Related Videos
Related Concept Videos
Imaging Studies for Cardiovascular System V: CT
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Acute Coronary Syndrome III: Diagnostic Studies
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm III: Interprofessional Care

