Cancer, cadmium and genome integrity

A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad.

Nature communications·2026

PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.

Cancer research·2026

Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1.

bioRxiv : the preprint server for biology·2026

Double strand breaks drive toxicity in a Huntington's disease mouse model with or without somatic expansion.

Nature communications·2026

Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience.

Cancers·2026

DPY30 Is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer.

Cancer research·2026

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

Nature genetics·2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Nature genetics·2026

Correlations between causal effect sizes of proximal SNPs vary with functional annotations and implicate stabilizing selection.

Nature genetics·2026

hnRNPK condensates facilitate enhancer-promoter looping and RNA polymerase II recruitment.

Nature genetics·2026

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.

Nature genetics·2026

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.

Nature genetics·2026

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma.

The Laryngoscope·2026

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract.

Clinical and translational medicine·2026

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era.

Cell proliferation·2026

Related Experiment Videos

Cancer, cadmium and genome integrity

Related Concept Videos

A unified catalytic mechanism in bifunctional DNA glycosylases with an evolutionarily conserved aspartate-lysine dyad.

PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.

Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1.

Double strand breaks drive toxicity in a Huntington's disease mouse model with or without somatic expansion.

Characteristics and Clinical Outcomes of BRCA Germline Mutation Carriers with Advanced Breast Cancer Treated with PARP (Poly ADP-Ribose Polymerase) Inhibitors: A Single-Institution Experience.

DPY30 Is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer.

Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Correlations between causal effect sizes of proximal SNPs vary with functional annotations and implicate stabilizing selection.

hnRNPK condensates facilitate enhancer-promoter looping and RNA polymerase II recruitment.

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer's disease.

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer.

Genetic Mutations in Recurrent/Metastatic Papillary Thyroid Carcinoma.

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract.

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era.

Related Experiment Videos

Cancer, cadmium and genome integrity

Related Concept Videos

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