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The structure of the Ca2+-ATPase of sarcoplasmic reticulum
Anthony N Martonosi1, Slawomir Pikula
1Upstate Medical University, College of Graduate Studies, State University of New York, Syracuse, NY, U.S.A.
Acta Biochimica Polonica
|July 2, 2003
Abstract:
In this article the morphology of sarcoplasmic reticulum, classification of Ca(2+)-ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology will be reviewed. The focus is on the structure and interactions of Ca(2+)-ATPase determined by electron and X-ray crystallography, lamellar X-ray and neutron diffraction analysis of the profile structure of Ca(2+)-ATPase in sarcoplasmic reticulum multilayers. In addition, targeting of the Ca(2+)-ATPase to the sarcoplasmic reticulum is discussed.