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Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
Published on: October 23, 2020
[Aortic debris in cerebrovascular ischemic disease]
L M Curatolo1, C M Melcón, M A Lourido
1Servicio de Neurología, Policlinica Bancaria, Buenos Aires, Argentina. neurologia@osba.com.ar
Insights
Aortic debris detected via transesophageal echocardiogram (TEE) is a significant embolic source in patients experiencing ischemic stroke. Many patients with aortic debris show a high incidence of lacunar infarcts, highlighting the importance of TEE in identifying embolic risks.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Diagnostic Imaging
Context:
- Aortic atherosclerotic debris is a recognized high-risk embolic source and an independent predictor of cerebrovascular ischemia.
- The incidence of aortic debris is notably higher in elderly individuals and those with pre-existing coronary artery disease.
- Transesophageal echocardiogram (TEE) serves as a crucial diagnostic tool for identifying aortic debris.
Purpose:
- To characterize patients diagnosed with ischemic stroke who also exhibit echocardiographic evidence of aortic debris.
Summary:
- A study analyzed 209 TEEs performed for 835 ischemic events, identifying aortic debris in 14% of cases.
- Patients with aortic debris (mean age 66.56 years) frequently presented with Grade IV plaques (60%), left atrial dilatation (40%), and spontaneous echo contrast (20%).
- Hypertension, dyslipidemia, and smoking were common risk factors, with 40% having a history of cerebrovascular events. Lacunar infarcts were prevalent (63%), particularly LACI subtypes.
Impact:
- Transesophageal echocardiogram (TEE) plays a vital role in detecting potential embolic sources.
- A significant proportion of patients with echocardiographically diagnosed aortic debris experience lacunar infarcts, underscoring the clinical relevance of this finding.
Background:
The aortic atherosclerotic debris is considered a high risk embolic source, being an independent predictor for cerebrovascular ischemia. The incidence is higher in the elderly and in patients with coronary artery disease. Transesophageal echocardiogram (TEE) is an important diagnostic tool that allows its detection.
Objective:
To describe characteristics of patients with ischemic stroke and echocardiographic diagnosis of aortic debris.
Patients And Methods:
We analyzed the group of patients with debris diagnosis in 209 TEE performed between 01/01/99 and 31/05/02, in 835 consecutive ischemic events. The information was collected from the Stroke Database of the Neurology Department of Policlinica Bancaria.
Results:
TEE was accomplished in 25% of all assisted events. The mean age was 66.56 years (SD 11.22). In 30 studies (14%) aortic debris was detected. In this group of patients, 26 men and 4 women, was also found: plaques grade IV 60%, left atrial dilatation 40% and spontaneous echo contrast 20%. The most frequent risk factors were hypertension, dislipemia and smoking, with no significative difference compared to the group without debris. 40% had a prior cerebrovascular event. They presented with clinical subtype LACI 53%, PACI 27%, POCI 17%. 63% of patients had lacunar infarct (53% anterior and 10% posterior).
Conclusion:
The contribution of TTE for detection of embolic sources is relevant. A high percentage of the population with echocardiographic diagnosis of aortic debris, had a lacunar infarct, defined radiologically and by clinical features.
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