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Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Noninvasive bone replacement with a new injectable calcium phosphate biomaterial
O Gauthier1, I Khairoun, J Bosco
1Laboratoire de Recherche sur les Matériaux d'Intérêt Biologique INSERM 99-03, Faculté de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes Cedex 01, France.
Journal of Biomedical Materials Research. Part A
|July 2, 2003
Summary
Injectable biphasic calcium phosphate (BCP) granules offer superior bone regeneration compared to bone cement. This injectable bone substitute facilitates faster bone formation and material degradation for better surgical outcomes.
Area of Science:
- Biomaterials Science
- Orthopedic Surgery
- Regenerative Medicine
Background:
- Injectable calcium phosphate (CaP) biomaterials are crucial for bone regeneration in minimally invasive surgery.
- Two main types are under development: ionic hydraulic bone cements and injectable bone substitutes (IBS) comprising biphasic calcium phosphate (BCP) ceramic granules in a polymer vehicle.
Purpose of the Study:
- To compare the in vivo performance of BCP-based IBS with ionic hydraulic bone cement for bone regeneration.
- To evaluate bone colonization, implantation efficiency, and biomaterial degradation.
Main Methods:
- Physicochemical characterization of biomaterials.
- In vivo evaluation in rabbit bone models using light microscopy, scanning electron microscopy, and synchrotron-based 3D microtomography.
Main Results:
- Both biomaterials demonstrated excellent biocompatibility and bioactivity after 3 weeks.
- BCP granules showed significantly greater new bone formation and faster degradation than ionic cement.
- Newly formed bone integrated BCP granules, while cement showed only surface ossification with minimal degradation.
Conclusions:
- BCP granules in a polymer vehicle provide superior bone substitution compared to carbonated-hydroxyapatite bone cement.
- The interconnected porosity of IBS facilitates rapid integration with host bone and potential for therapeutic agent delivery.
- This injectable bone substitute shows promise for advancing microinvasive bone surgery.
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