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Systemic lupus erythematosus and chronic lymphocytic leukemia: rare coexistence in three patients, with comments on
G Lugassy1, M Lishner, A Polliack
1Institute of Hematology, Barzilai Medical Center, Ashkelon, Israel.
Insights
This study reports on three patients with both chronic lymphatic leukemia (CLL) and systemic lupus erythematosus (SLE). The findings highlight a rare co-occurrence of these distinct conditions, prompting further investigation into their relationship.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- The association between autoimmune diseases and lymphoproliferative disorders is recognized.
- Systemic lupus erythematosus (SLE) is an autoimmune condition, while chronic lymphatic leukemia (CLL) is a lymphoproliferative malignancy.
- Coexistence of SLE and CLL is infrequently reported in medical literature.
Observation:
- Three cases of patients presenting with both SLE and CLL are described.
- In two cases, CLL was diagnosed before or concurrently with SLE.
- In one case, CLL developed five years after the initial SLE diagnosis.
Findings:
- The study details the clinical course and diagnostic timelines for these three patients.
- It underscores the rarity of simultaneous or sequential diagnosis of CLL and SLE.
- The temporal relationship between the onset of CLL and SLE varied among the patients.
Implications:
- Further research into the potential shared or interacting pathogenetic mechanisms underlying SLE and CLL is warranted.
- Understanding this rare association may improve diagnostic strategies and patient management.
- This case series contributes to the limited existing data on the co-occurrence of these two distinct diseases.
Abstract:
We describe three patients with coexistent chronic lymphatic leukemia (CLL) and systemic lupus erythematosus (SLE). In two patients, the CLL was present before or coexistent with the SLE when the SLE was diagnosed, while in the third, the CLL developed 5 years after the diagnosis of SLE was first made. Although the association of autoimmune diseases and lymphoproliferative disorders is well established, only a few patients with coexistent CLL and concomitant SLE have been reported. The possible pathogenesis of this rare association is discussed.