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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Transplantation: tolerance

Anne Hutchings1, Judith M Thomas

  • 1Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ahutchings@uab.edu

Current Opinion in Investigational Drugs (London, England : 2000)
|July 2, 2003
PubMed

The immunosuppressive regimens currently in use have been responsible for major improvements in transplanted organ acceptance, but long-term survival can be compromised by drug toxicity and/or chronic immune deficiency. The ultimate goal for transplantation is tolerance, defined as durable, donor-specific allograft acceptance in the absence of long-term immunosuppression. This review describes current experimental strategies for tolerance induction in primate models that are poised for clinical application.

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