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Transplantation: tolerance.

Anne Hutchings¹, Judith M Thomas

¹Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ahutchings@uab.edu

Current Opinion in Investigational Drugs (London, England : 2000)

|July 2, 2003

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Achieving organ transplant tolerance, or donor-specific acceptance without immunosuppression, is key. This review explores experimental strategies in primate models for inducing tolerance, aiming for clinical application.

Area of Science:

Transplantation immunology
Immunosuppression
Tolerance induction

Background:

Current immunosuppressive drugs improve organ acceptance but cause toxicity and immune deficiency.
Long-term transplant survival is limited by these adverse effects.
The goal is achieving transplant tolerance, enabling acceptance without long-term immunosuppression.

Purpose of the Study:

To review experimental strategies for inducing transplant tolerance.
To focus on strategies tested in primate models.
To identify approaches ready for clinical application.

Main Methods:

Review of current experimental tolerance induction strategies.
Focus on studies utilizing primate models.
Assessment of strategies for clinical translatability.

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Main Results:

Primate models are crucial for testing tolerance induction strategies.
Several experimental approaches show promise for achieving donor-specific acceptance.
These strategies are being evaluated for their potential in human clinical trials.

Conclusions:

Advancing transplant tolerance is critical for improving long-term outcomes.
Experimental strategies in primate models offer a pathway to reduced immunosuppression.
Clinical application of tolerance induction methods is an active area of research.