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Anti-inflammatory activity of shikonin derivatives from Arnebia hispidissima

B Singh¹, M K Sharma, P R Meghwal

¹Department of Botany, University of Rajasthan, Jaipur, India.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

|July 2, 2003

Abstract:

Arnebia hispidissima ethanolic extract, after chromatography, yielded a number of shikonin derivatives, which were identified as arnebin-5, arnebin-6, teracryl shikonin, arnebinone and acetyl shikonin. All these compounds were firstly reported from this plant species and evaluated to the anti-inflammatory activity of ethanolic extract and isolated shikonin derivatives, models with carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The observed results indicated that pre-treatment with arnebinone significantly inhibited the carrageenan-induced paw edema and also suppressed the development of chronic arthritis induced by CFA.

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Antibodies consist of four polypeptide chains: two identical heavy...

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