Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of diabetic sexual dysfunction.

S Morano1

  • 1Department of Clinical Sciences, Endocrinology, University "La Sapienza", Rome, Italy. susanna.morano@uniroma1.it

Journal of Endocrinological Investigation
|July 2, 2003
PubMed
Summary

Diabetes mellitus frequently causes sexual dysfunction in men and women due to vascular, neurological, and hormonal changes. Erectile dysfunction (ED) in men and vaginal dryness in women are common, impacting quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19 vaccine and autoimmune diabetes in adults: report of two cases.

Journal of endocrinological investigation·2022
Same author

[Gender Diversity and Impact on Work and Life Expectancy in Health Care. Results of a Survey Conducted in the Tuscany Region].

Igiene e sanita pubblica·2021
Same author

Human cell-based anti-inflammatory effects of rosiglitazone.

Journal of endocrinological investigation·2021
Same author

Anti-Müllerian hormone as marker of ovarian reserve in patients with long-standing type 1 diabetes.

Journal of biological regulators and homeostatic agents·2020
Same author

Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies.

Journal of endocrinological investigation·2020
Same author

COVID-19: is there a link between the course of infection and pharmacological agents in diabetes?

Journal of endocrinological investigation·2020

Area of Science:

  • Endocrinology
  • Urology
  • Vascular Biology

Background:

  • Diabetes mellitus is a common condition associated with numerous complications.
  • Sexual dysfunction, including erectile dysfunction (ED) in men and vaginal dryness in women, is a prevalent issue in diabetic patients.
  • The pathophysiology involves vascular, neurological, and hormonal alterations.

Purpose of the Study:

  • To review the mechanisms underlying sexual dysfunction in patients with diabetes mellitus.
  • To highlight the impact of diabetes on both male and female sexual health.
  • To discuss the role of vascular, neurological, and hormonal factors.

Main Methods:

  • Review of existing literature on diabetes mellitus and sexual dysfunction.
  • Analysis of studies investigating endothelial and neurogenic functions in diabetic corpus cavernosum.
  • Examination of the role of advanced glycation endproducts (AGEs), nitric oxide (NO), nitric oxide synthase (NOS), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and androgens.
  • Inclusion of research on neuropathy and sexual dysfunction in women.

Main Results:

  • Diabetes induces vascular complications, including altered NO production and increased NOS binding sites, contributing to ED.
  • Advanced glycation endproducts (AGEs) impair NO activity and promote vascular damage mediators like VEGF and ET-1.
  • Neuropathy and hormonal changes, such as decreased androgen levels, play significant roles in diabetic ED.
  • Sexual dysfunction in diabetic women, characterized by vaginal lubrication issues, is under-researched but linked to marital and mental health issues.

Conclusions:

  • Sexual dysfunction in diabetes is multifactorial, involving vascular, neurological, and hormonal pathways.
  • ED in diabetic men is linked to endothelial dysfunction, neuropathy, and hormonal imbalances.
  • Sexual dysfunction in diabetic women warrants further research due to its significant impact on quality of life.

Related Experiment Videos