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Related Experiment Videos

Massive amoxycillin crystalluria causing anuric acute renal failure.

L Labriola1, M Jadoul, M Daudons

  • 1Division of General Internal Medicine, Cliniques Universitaires St. Luc, Université Catholique de Louvain, Brussels, Belgium.

Clinical Nephrology
|July 2, 2003
PubMed
Summary

A woman developed acute kidney injury after amoxicillin-clavulanate treatment for pneumonia. Kidney function recovered upon antibiotic withdrawal, revealing amoxicillin crystals in urine, suggesting drug-induced crystalluria as a cause.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Internal Medicine

Background:

  • Pneumonia is a common infection requiring antibiotic treatment.
  • Amoxicillin-clavulanate is a frequently prescribed antibiotic combination.
  • Acute kidney injury (AKI) is a potential complication of various medical conditions and treatments.

Observation:

  • A 45-year-old female patient presented with anuric AKI after 12 days of intravenous amoxicillin-clavulanate therapy for pneumonia.
  • The patient's renal function rapidly and completely normalized after discontinuation of the antibiotic.
  • Urine analysis revealed numerous crystals, identified as trihydrated amoxicillin via infrared spectrophotometry.

Findings:

  • Intravenous amoxicillin-clavulanate can cause acute renal failure.

Related Experiment Videos

  • Massive crystalluria composed of amoxicillin can lead to intrarenal obstruction.
  • Drug-induced crystalluria is a potential cause of acute anuria.

    • Implications:

    • Clinicians should consider amoxicillin-clavulanate-induced crystalluria in patients presenting with unexplained anuric AKI.
    • Prompt recognition and withdrawal of the offending antibiotic are crucial for renal recovery.
    • This case highlights the importance of monitoring renal function during prolonged antibiotic therapy, especially with agents known to cause crystalluria.