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Psoriasis, vasculitis and methotrexate.

J C Moreno1, A Vélez, I Medina

  • 1Department of Dermatology, Reina Sofía University Hospital, Córdoba, Spain. md1mogij@uco.es

Journal of the European Academy of Dermatology and Venereology : JEADV
|July 2, 2003
PubMed
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Psoriasis and vasculitis rarely occur together. This report details two cases where psoriasis, vasculitis, and kidney disease co-occurred, potentially triggered by methotrexate treatment.

Area of Science:

  • Dermatology
  • Nephrology
  • Rheumatology

Background:

  • The co-occurrence of psoriasis and vasculitis is infrequently documented in medical literature.
  • Previous reports have linked this association primarily to extensive forms of psoriasis, including psoriatic arthritis.

Observation:

  • This paper presents two distinct cases involving patients with concurrent psoriasis, vasculitis, and nephropathy.
  • Both patients exhibited a clinical presentation where these three conditions were simultaneously present.

Findings:

  • Methotrexate therapy was identified as a potential causative agent in both described cases.
  • The data suggests that methotrexate may act as a trigger for the development of vasculitis and nephropathy in patients with psoriasis.

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Implications:

  • These findings highlight a potential adverse effect of methotrexate, necessitating careful monitoring in patients with psoriasis.
  • Further research is warranted to elucidate the precise mechanisms by which methotrexate might induce this triad of conditions.
  • Clinicians should consider methotrexate-induced vasculitis and nephropathy in patients with psoriasis presenting with these symptoms.