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Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors
Hyun Joon Kim1, Jeong Eun Kim, Myung Ha
1Department of Anatomy, Institute of Health Science, College of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, South Korea.
Abstract:
In this study we found the expression of steroidogenic acute regulatory protein (StAR) mRNA and protein in both the normal human brain and intracranial tumors, using RT-PCR and immunohistochemistry. StAR mRNA is expressed at a very low level in the white matter of the normal human brain, but in tumoral tissues StAR mRNA was specifically expressed in oligodendrogliomas and malignant glial tumors. StAR-positive cells were also detected in the normal human brains and gliomas; its frequency and density were higher in glioma tissue. These findings suggest that StAR expression might be correlated with the growth of glial tumors.
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