Permeation of captan through disposable nitrile glove

The purpose of this study was to investigate the permeation of an aqueous emulsion of the pesticide, captan, as a wettable powder (48.9% captan) through a disposable nitrile glove material using an American Society for Testing and Materials (ASTM)-type I-PTC-600 permeation cell. The goal was to investigate the protective capability of the gloves against dermatitis. The analytical method was based on gas chromatography-mass spectrometry (GC-MS) and gas chromatography-electron capture detection (GC-ECD). The least quantifiable limit (LQL) was 6 ng for GC-ECD and 30 ng for GC-MS. Testing was conducted using the ASTM F739 closed-loop permeation method and a worst-case aqueous concentration 217 mg/ml of captan 50-WP. The average permeation rates were low, with 12+/-5 ng/(cm(2)min) after 2h, 50+/-25 ng/(cm(2)min) after 4h, and 77+/-58 ng/(cm(2)min) after 8h. The calculated diffusion coefficient was (1.28+/-0.10) x 10(-5)cm(2)/h. No significant swelling or shrinkage occurred at P