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AIDS-associated mucocutaneous Kaposi's sarcoma treated with bleomycin
E Caumes1, G Guermonprez, C Katlama
1Département de Médecine Tropicale, Maladies Infectieuses, Parasitologie, Mycologie et Santé Publique, Hôpital de la Salpêtrière, Paris, France.
Objectives:
To evaluate efficacy and tolerance of bleomycin in AIDS-associated mucocutaneous Kaposi's sarcoma. A previous study showed that bleomycin was effective and well tolerated in this setting.
Design:
A non-comparative, open, prospective study.
Methods:
Seventy patients were treated with 5 mg per day intramuscular bleomycin on 3 consecutive days every 2 weeks.
Results:
Two patients achieved a complete response and 50 a partial response (overall response rate, 74%). Median time to treatment response was 4 weeks (range, 2-12 weeks) and median time to relapse 10 weeks (range, 2-36 weeks). Dose-limiting toxicity consisted of cutaneous adverse reactions.
Conclusion:
Bleomycin is active against AIDS-associated mucocutaneous Kaposi's sarcoma; relapse occurs after discontinuation of therapy.