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Updated: Sep 23, 2026

Telomerase Activity in the Various Regions of Mouse Brain: Non-Radioactive Telomerase Repeat Amplification Protocol (TRAP) Assay
Published on: September 2, 2014
A study on telomerase activity and prognosis in breast cancer
M Kimura1, T Koida, Y Yanagita
1Department of Surgery, Gunma Cancer Center, 617-1 Takabayashi-nishi, Ohta City, Gunma 373-8550, Japan. mkimura@gk9.50-net.ne.jp
Abstract:
There are still many questions to be elucidated concerning the relationship between telomerase activity and various factors associated with cancer. Whether or not the level of telomerase activity could be a prognostic factor in breast cancer was investigated through 5-yr follow-up observation. Telomerase activity was quantified by the fluorescence-based telomeric repeat amplification protocol assay in 54 patients with breast cancer and its relationship with patient prognosis was examined. Telomerase activity was detected in 92.6% of breast cancer patients, with a median of 65.4 TPG (total product generated) (Min 0-Max 446.2). The follow-up observation for 5 yr demonstrated that among background factors examined, recurrence was the only factor that showed a significant association with the level of telomerase activity when a cutoff at 100 TPG was adopted. This suggested the possibility of 100 TPG telomerase activity being a prognostic factor for recurrence. Prospective studies will be necessary to clarify this matter.
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