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Related Experiment Videos

Decrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease.

K K Yung1, F Tang, L L Vacca-Galloway

  • 1Department of Anatomy, Faculty of Medicine, University of Hong Kong.

Brain Research
|December 18, 1992
PubMed
Summary
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Wobbler mice with inherited motoneuron disease show altered neuropeptide levels. Lower enkephalin and higher substance P in the cerebellum suggest these changes are key to the Wobbler disorder.

Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • The Wobbler mouse model exhibits an inherited motoneuron disease.
  • Disease pathology primarily affects cervical spinal cord and cranial motor nuclei.
  • Other brain regions like the cerebellum and corpus striatum show minimal cell degeneration.

Purpose of the Study:

  • To investigate neuropeptide concentration changes in the Wobbler mouse model.
  • To determine the role of specific peptides in the disease's etiology.
  • To compare peptide levels between affected mice and normal littermates.

Main Methods:

  • Analysis of neuropeptide concentrations (enkephalin, substance P, TRH) in specific brain regions.
  • Comparison of peptide levels in Wobbler mice versus normal littermates.

Related Experiment Videos

  • Focus on cerebellum, spinal cord, brainstem, and corpus striatum.

    • Main Results:

    • Consistently lower enkephalin concentrations in Wobbler cerebellum.
    • Significantly higher substance P concentrations late in the disease in Wobbler mice.
    • Enkephalin changes (including leucine enkephalin) observed in spinal cord and brainstem.
    • Thyrotropin-releasing hormone (TRH) and other peptides remained unchanged in specific regions.

    Conclusions:

    • Early alterations in enkephalin may be crucial to the Wobbler disorder's development.
    • Increased substance P late in the disease might indicate a response to neuronal degeneration.
    • These neuropeptide changes offer insights into the pathogenesis of inherited motoneuron diseases.