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Quantification of the in vitro activity of some compounds with spermicidal activity
E Chantler1, H Fisher, S Solanki
1Department of Obstetrics and Gynaecology, University Hospital of South Manchester.
Contraception
|December 1, 1992
Abstract:
The in vitro spermicidal activity of the commonly used surfactant spermicides and the antiseptic chlorhexidine, were quantified in a statistically reproducible manner, using donor semen and image capture analysis. The spermicidal activity was expressed as the ED50 under defined assay conditions. Using these parameters, the order of spermicidal activity was: Menfegol > nonoxynol-9 approximately benzalkonium chloride > sodium docusate > chlorhexidine. These differences were statistically significant.
Keywords:
Clinical ResearchContraceptionContraceptive AgentsContraceptive EffectivenessContraceptive MethodsDeveloped CountriesEnglandEuropeFamily PlanningIn VitroNonoxynol-9Northern EuropeResearch MethodologyResearch ReportSperm Immobilizing AgentsSpermicidal Contraceptive AgentsTheoretical EffectivenessUnited KingdomVaginal Spermicides