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Updated: Sep 23, 2026

Essential Metal Uptake in Gram-negative Bacteria: X-ray Fluorescence, Radioisotopes, and Cell Fractionation
Published on: February 1, 2018
The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)
Andrew T McKie1, David J Barlow
1Division of Life Sciences, Kings College London, Franklin-Wilkins Building, 150 Stamford Street, SE1 9NN, London, UK. andrew.t.mckie@kcl.ac.uk
Abstract:
The iron regulated-transporter-1 (Ireg1, also known as ferroportin or metal transporter protein-1, MTP1) appears to be the sole member of the SLC40 transporter family. It functions as a universal efflux pathway for iron in a number of cell types. The protein is most highly expressed in mature enterocytes of the duodenum, in syncytiotrophoblasts, which separate foetal and maternal circulations in the placenta, and in macrophages responsible for recycling iron from breakdown of aged red blood cells.
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