Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cadherin superfamily database.

Kevin Truong1, Mitsuhiko Ikura

  • 1Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Journal of Structural and Functional Genomics
|July 3, 2003
PubMed
Summary

A new tool classifies cadherin superfamily proteins, improving functional annotation accuracy. This aids researchers studying cell adhesion and signaling by providing more specific insights than current databases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Allosteric Targeting of the ACE2 Dimer Interface by a Medium-sized Compound Inhibits SARS-CoV-2 Entry.

Journal of molecular biology·2026
Same author

Estimating genotype-tissue specific gene expression using hybrid deep learning.

Communications biology·2026
Same author

Prompt-Only Gene-Circuit Modeling with a Large Language Model Simulates the synNotch Spheroids.

ACS synthetic biology·2026
Same author

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.

iScience·2025
Same author

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.

eLife·2025
Same author

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

bioRxiv : the preprint server for biology·2025

Area of Science:

  • Proteomics
  • Bioinformatics
  • Molecular Biology

Background:

  • The cadherin superfamily is a large, diverse protein family crucial for cell adhesion and signaling.
  • Existing databases offer broad classification, but specific functional annotation requires subfamily-level analysis.
  • Managing and analyzing cadherin superfamily sequences is vital due to growing biological interest.

Purpose of the Study:

  • To develop a computational tool for classifying cadherin superfamily protein sequences.
  • To enhance functional annotation accuracy for cadherin members.
  • To create a web-accessible database for cadherin sequence analysis.

Main Methods:

  • Development of a classification tool for cadherin superfamily proteins.
  • Application of the tool to analyze sequences in the SWISS PROT database.

Related Experiment Videos

  • Integration of the tool and analysis results into a web database.

    • Main Results:

    • The tool successfully classified over 90% of cadherin superfamily proteins in SWISS PROT.
    • Achieved more specific functional annotations compared to current profile and motif databases.
    • Established a web-accessible resource for cadherin research.

    Conclusions:

    • The developed tool significantly improves the functional annotation of cadherin superfamily proteins.
    • The web database provides a valuable resource for researchers in cell adhesion and signaling.
    • This work advances the understanding and analysis of the diverse cadherin protein family.