Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biflavonoids from Podocalyx loranthoides.

Alírica I Suárez1, Beth Diaz M, Franco Delle Monache

  • 1Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve

Fitoterapia
|July 3, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sertraline as a Scaffold for Antitrypanosoma Cruzi Drug Development: Design of Novel Derivatives and Computational Target Screening.

ChemMedChem·2025
Same author

Chemical Characterization and Enantioselective Analysis of <i>Tagetes filifolia</i> Lag. Essential Oil and Crude Extract.

Plants (Basel, Switzerland)·2024
Same author

Antiviral activity of myricetin glycosylated compounds isolated from <i>Marcetia taxifolia</i> against chikungunya virus.

EXCLI journal·2023
Same author

Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives.

Pharmaceuticals (Basel, Switzerland)·2021
Same author

Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from <i>Fabiana densa</i> var. <i>ramulosa</i>.

ACS medicinal chemistry letters·2020
Same author

Cytotoxic Property of <i>Grias neuberthii</i> Extract on Human Colon Cancer Cells: A Crucial Role of Autophagy.

Evidence-based complementary and alternative medicine : eCAM·2020
Same journal

Integrating LC-MS and network pharmacology to uncover the mechanism of antidepressant effects of Illigera aromatica ethanol extract in rodent models.

Fitoterapia·2026
Same journal

Pharmacokinetic characteristics of Bletilla Striata active components in rats and <sup>1</sup>H NMR metabolomics study on ulcerative colitis.

Fitoterapia·2026
Same journal

The cellular and molecular mechanisms of linalool in cancer therapy: Recent advances.

Fitoterapia·2026
Same journal

Phytocomplexes as dual modulators of redox homeostasis and autophagy in host-directed antiviral therapy.

Fitoterapia·2026
Same journal

Contribution of polyphenols in wine grape extract to the inhibition of serine protease activity and proteinase-activated receptor 1-mediated Ca<sup>2+</sup> signaling in vascular endothelial cells.

Fitoterapia·2026
Same journal

Mechanistic insights into a compound essential oil (lemon-Angelica sinensis-Boswellia) for anxiety-melasma comorbidity: An integrated network pharmacology and experimental study.

Fitoterapia·2026
See all related articles

Researchers isolated two compounds, I 7, II 4'-dimethylamentoflavone and II 4'-methylamentoflavone, from Podocalyx loranthoides. The first compound showed moderate activity against Leishmania mexicana.

Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Parasitology

Background:

  • Podocalyx loranthoides is a plant species with potential medicinal properties.
  • Flavonoids are a class of plant secondary metabolites known for diverse biological activities.

Purpose of the Study:

  • To isolate and identify chemical constituents from the ethyl acetate extract of Podocalyx loranthoides aerial parts.
  • To evaluate the in vitro activity of isolated compounds against Leishmania mexicana promastigotes.

Main Methods:

  • Phytochemical analysis of the ethyl acetate extract using chromatographic techniques.
  • Isolation and structural elucidation of compounds using spectroscopic methods.
  • Antiparasitic activity testing against Leishmania mexicana promastigotes.

Related Experiment Videos

Main Results:

  • Two biflavonoids, I 7, II 4 -dimethylamentoflavone (1) and II 4 -methylamentoflavone (2), were successfully isolated.
  • Compound (1) demonstrated moderate inhibitory activity against Leishmania mexicana promastigotes in vitro.

Conclusions:

  • Podocalyx loranthoides contains bioactive biflavonoids.
  • I 7, II 4 -dimethylamentoflavone shows potential as a lead compound for developing new anti-Leishmania therapies.