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Evaluation of analgesic effect of Datura fastuosa leaves and seed extracts
A A Abena1, L M Miguel, A Mouanga
1Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, University Marien Ngouabi, BP 69, Brazzaville, Congo. abena_cg@yahoo.fr
Abstract:
The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. According to the results, D. fastuosa leaves and seeds extracts at oral doses of 400 and 800 mg/kg are effective as analgesic. The analgesic activity of leaf extract is reduced by naloxone but not that of seed extract.
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