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Urinary interleukin-8 levels are elevated in subjects with transitional cell carcinoma
Elinore Sheryka1, Marcia A Wheeler, Derek A Hausladen
1Section of Urology, Yale University School of Medicine, New Haven, Connecticut 06520-8041, USA.
Urology
|July 3, 2003
Summary
Elevated urinary Interleukin-8 (IL-8) levels indicate active bladder cancer (transitional cell carcinoma, TCC). Higher IL-8 correlates with invasive TCC and recurrence after treatment, suggesting its role in tumor progression.
Area of Science:
- Oncology
- Urology
- Immunology
Background:
- Interleukin-8 (IL-8) is an angiogenic factor implicated in various cancers.
- Elevated IL-8 in urine may serve as a biomarker for active transitional cell carcinoma (TCC).
Purpose of the Study:
- To investigate urinary IL-8 levels as a potential diagnostic and prognostic marker for TCC.
- To assess the correlation between urinary IL-8 levels and TCC stage and recurrence.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure urinary IL-8 levels.
- Subjects included patients with TCC, prostate cancer, treated TCC, and healthy controls.
- Urinary IL-8 was also measured in patients undergoing intravesical therapy.
Main Results:
- Urinary IL-8 levels were significantly higher in patients with active TCC compared to healthy subjects, prostate cancer patients, and those with a history of treated TCC.
- Higher IL-8 levels were observed in subjects with invasive (high-stage) TCC versus low-stage TCC.
- Post-treatment IL-8 levels were elevated in patients experiencing TCC recurrence.
Conclusions:
- Urinary IL-8 is a potential biomarker for active TCC, with levels increasing with tumor invasiveness.
- Changes in urinary IL-8 levels post-treatment may reflect treatment efficacy and disease status.