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Related Experiment Videos

Heart rate variability during interictal epileptiform discharges.

Megdad M Zaatreh1, Stephen R Quint, Michael B Tennison

  • 1Department of Neurology, University of North Carolina, Chapel Hill, NC 27599-7025, USA. mmzid@med.unc.edu

Epilepsy Research
|July 3, 2003
PubMed
Summary

Seizures can alter heart rate variability. Interictal epileptiform discharges (IEDs) in epilepsy patients showed significant changes in RR intervals, suggesting IEDs influence autonomic control.

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Area of Science:

  • Epilepsy research
  • Autonomic nervous system function
  • Cardiac electrophysiology

Background:

  • Seizures can cause autonomic nervous system alterations through reflexes or direct cortical effects.
  • Animal studies demonstrate a link between interictal discharges and autonomic output.
  • This association is less understood in human epilepsy.

Purpose of the Study:

  • To investigate the relationship between interictal epileptiform discharges (IEDs) and autonomic control of the cardiac cycle in humans.
  • To compare heart rate variability changes associated with IEDs in focal onset epilepsy patients.

Main Methods:

  • Analyzed RR intervals (RR(n)) locked to IEDs and compared them to subsequent intervals (RR(n+1)).
  • Studied 40 patients with focal onset epilepsy and low baseline heart rate variability.

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  • Examined 200 left-sided and 200 right-sided IEDs per patient group.

    • Main Results:

    • Significant changes in RR intervals were observed following IEDs (Chi square P<0.001).
    • Left-sided IEDs showed varied effects: 100 shortened RR(n) and 31 prolonged RR(n) compared to RR(n+1).
    • Right-sided IEDs predominantly prolonged RR(n): 17 shortened and 116 prolonged compared to RR(n+1).

    Conclusions:

    • Interictal epileptiform discharges can influence autonomic control of the heart rate, aligning with animal study findings.
    • Further research is needed to clarify the specific lateralized influences of IEDs on the autonomic nervous system.