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Biochemical indicator for evaluation of connective tissue abnormalities in Menkes' disease
Hiroko Kodama1, Emi Sato, Yukisige Yanagawa
1Department of Pediatrics, Teikyo University School of Medicine, Tokyo Metropolitan Hachioji Children's Hospital, Ibaraki University, Tokyo, Japan. hkodama@med.teikyo-u.ac.jp
The Journal of Pediatrics
|July 3, 2003
Abstract:
Metabolites of collagen metabolism were analyzed in patients with Menkes' disease. The urinary deoxypyridinoline level was significantly low in the patients with Menkes' disease, indicating that it is a good marker of lysyl oxidase activity, which is related to the connective tissue abnormalities.