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Updated: Aug 10, 2026

Protein Target Prediction and Validation of Small Molecule Compound
Published on: February 23, 2024
Implications of protein flexibility for drug discovery
1AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leicester LE11 5RH, UK. simon.teague@astrazeneca.com
Abstract:
Proteins are in constant motion between different conformational states with similar energies. This has often been ignored in drug design. However, protein flexibility is fundamental to understanding the ways in which drugs exert biological effects, their binding-site location, binding orientation, binding kinetics, metabolism and transport. Protein flexibility allows increased affinity to be achieved between a drug and its target. This is crucial, because the lipophilicity and number of polar interactions allowed for an oral drug is limited by absorption, distribution, metabolism and toxicology considerations.
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