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Extracellular calcium sensing and signalling.

Aldebaran M Hofer1, Edward M Brown

  • 1West Roxbury Veterans Affairs Medical Center and Brigham and Women's Hospital, Department of Surgery, Harvard Medical School, Room 2B111, 1400 VFW Parkway, West Roxbury, Massachusetts 02132, USA. ahofer@rics.bwh.harvard.edu

Nature Reviews. Molecular Cell Biology
|July 3, 2003
PubMed
Summary
This summary is machine-generated.

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Extracellular calcium (Ca2+) acts as a messenger outside cells, detected by the calcium-sensing receptor. This G-protein-coupled receptor relays extracellular Ca2+ concentration information into cells, revealing new signaling functions.

Area of Science:

  • Cellular biology
  • Molecular signaling
  • Physiology

Background:

  • Calcium ions (Ca2+) are recognized as crucial intracellular second messengers.
  • The discovery of the extracellular calcium-sensing receptor (CaSR) challenges this view.
  • The CaSR enables extracellular Ca2+ to act as a signaling molecule.

Purpose of the Study:

  • To explore emerging concepts of extracellular Ca2+ signaling.
  • To emphasize the role of the CaSR in this process.

Main Methods:

  • Review of emerging scientific literature.
  • Focus on the molecular identification and function of the CaSR.

Main Results:

  • Extracellular Ca2+ concentration is communicated intracellularly via the CaSR.

Related Experiment Videos

  • The CaSR is a G-protein-coupled receptor.
  • New signaling paradigms for extracellular Ca2+ are emerging.

    • Conclusions:

    • The CaSR is pivotal in mediating extracellular Ca2+ signals.
    • Ca2+ functions as a messenger both inside and outside cells.
    • Further research into CaSR-mediated signaling is warranted.