Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human and mouse proteases: a comparative genomic approach.

Xose S Puente1, Luis M Sánchez, Christopher M Overall

  • 1Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

Nature Reviews. Genetics
|July 3, 2003
PubMed
Summary

Genome sequencing enables the study of degradomes, the full set of proteases in humans and mice. Understanding these protease functions is key to exploring cell behavior in health and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging.

Frontiers in aging·2026
Same author

Pro-aging effects of chronic glucocorticoid signaling.

Cell metabolism·2026
Same author

Exercise-induced changes in physical performance and circulating acyl-CoA binding protein/diazepam binding inhibitor (ACBP/DBI) in older adults with and without HIV.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

The long-lived immune system of centenarians.

Nature reviews. Immunology·2026
Same author

Exercise and the hallmarks of cardiovascular aging.

Ageing research reviews·2026
Same author

Correction: LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

PloS one·2025

Area of Science:

  • Biochemistry
  • Genomics
  • Proteomics

Background:

  • The human and mouse genome sequences are now available.
  • Proteases, also known as proteolytic enzymes, play crucial roles in cellular processes.
  • The complete set of proteases produced by an organism is termed its degradome.

Purpose of the Study:

  • To identify and compare the degradomes of humans and mice.
  • To establish degradome analysis as a framework for exploring protease functions.
  • To investigate protease-mediated functions in both normal and pathological conditions.

Main Methods:

  • Comparative genomics of human and mouse genomes.
  • Bioinformatic analysis for protease identification.
  • Degradome analysis.

Related Experiment Videos

Main Results:

  • Identification of the complete protease repertoire (degradome) in humans and mice.
  • Comparison of human and mouse degradomes.
  • Established the utility of degradome analysis.

Conclusions:

  • Degradome analysis is a valuable approach for understanding protease functions.
  • Protease-mediated functions are critical in cell behavior, survival, and death.
  • This framework aids in exploring physiological and disease states.