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Human KIR sequences 2003.

C A Garcia1, J Robinson, L A Guethlein

  • 1Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, UK.

Immunogenetics
|July 3, 2003
PubMed
Summary
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This study compiles 89 Killer Immunoglobulin-like Receptor (KIR) allele sequences and translations. The curated data ensures accuracy for Killer Immunoglobulin-like Receptor (KIR) research.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Genomics

Background:

  • Killer Immunoglobulin-like Receptors (KIRs) are crucial in immune regulation.
  • Understanding KIR diversity is essential for immunological studies.
  • Previous compilations lacked comprehensive, verified sequence data.

Purpose of the Study:

  • To create a comprehensive and accurate compilation of Killer Immunoglobulin-like Receptor (KIR) nucleotide and amino acid sequences.
  • To establish a reliable reference dataset for KIR allele research.
  • To facilitate future studies on KIR gene diversity and function.

Main Methods:

  • Collected nucleotide sequences and amino acid translations for 89 KIR alleles from 17 KIR genes.
  • Utilized the KIR3DL2*001 allele as a reference sequence for alignment.

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  • Verified sequences through direct author contact and incorporated amendments to resolve discrepancies.

    • Main Results:

    • Successfully compiled and aligned sequences for 89 distinct Killer Immunoglobulin-like Receptor (KIR) alleles.
    • Established a high-quality dataset with verified and amended sequences.
    • The compilation serves as a foundational resource for KIR research.

    Conclusions:

    • The presented compilation offers a valuable and accurate resource for the scientific community.
    • This curated dataset will aid in advancing research on Killer Immunoglobulin-like Receptor (KIR) genetics and function.
    • Ongoing efforts to maintain data accuracy are emphasized for future sequencing updates.